منابع مشابه
Reversibility of spur cell anemia.
A diagnosis of spur cell anemia was made. Spur cell anemia is found in end-stage alcoholic liver disease. The morphologic changes of spur cells are caused by accumulation of excess membrane cholesterol, leading to an impaired deformability and consequently a reduced red cell survival. The prognosis of patients with spur cell anemia is poor, with a median survival of a few months. Liver transpla...
متن کاملSpur cell anemia associated with alcoholic cirrhosis.
A 56-year-old woman was admitted to our hospital with jaundice, massive ascites, hepatic encephalopathy and an intramuscular hematoma. She had severe liver dysfunction with a total bilirubin level of 9.0 mg/dL, indirect bilirubin level of 6.9 mg/dL, albumin level of 2.8 g/dL and prothrombin ratio of 43%. Her hemoglobin level was 6.8 g/dL, and a peripheral blood smear showed the presence of a la...
متن کاملAnemia with Spur
of chenodeoxycholic acid, with small amounts of lithocholic acid present as well. Spur cells manifested a striking increase in cholesterol content and in the cholesterol: phospholipid ratio, but a normal osmotic fragility. When incubated in heated normal serum, spur cells lost their excess cholesterol and became spherocytic and osmotically fragile. Conversely, sera from patients with spur cells...
متن کاملAbnormal phospholipid metabolism in spur cell anemia: decreased fatty acid incorporation into phosphatidylethanolamine and increased incorporation into acylcarnitine in spur cell anemia erythrocytes.
Spur cell anemia is a hemolytic anemia seen in severe alcoholic cirrhosis that is characterized by unusual morphology and a decreased ratio of phospholipids to cholesterol in the erythrocyte membrane. We hypothesized that defective phospholipid repair may contribute to the red blood cell (RBC) phospholipid abnormalities of spur cell anemia. Therefore, we compared RBCs from normal control subjec...
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ژورنال
عنوان ژورنال: The Hematologist
سال: 2019
ISSN: 1551-8779
DOI: 10.1182/hem.v16.5.9783